Reversal of Tumor-induced Dendritic Cell Paralysis by CpG Immunostimulatory Oligonucleotide and Anti–Interleukin 10 Receptor Antibody
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منابع مشابه
Reversal of Tumor-induced Dendritic Cell Paralysis by CpG Immunostimulatory Oligonucleotide and Anti–Interleukin 10 Receptor Antibody
Progressing tumors in man and mouse are often infiltrated by dendritic cells (DCs). Deficient antitumor immunity could be related to a lack of tumor-associated antigen (TAA) presentation by tumor-infiltrating DCs (TIDCs) or to a functional defect of TIDCs. Here we investigated the phenotype and function of TIDCs in transplantable and transgenic mouse tumor models. Although TIDCs could encompass...
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Background: Bacterial DNA has immunostimulatory effects on different types of immune cells such as dendritic cells (DCs). Application of DCs as a cellular adjuvant represents a promising approach in the immunotherapy of infectious disease and cancers. Objectives: To investigate the effect of tumor antigen pulsed DCs in the presence of CpG-1826 in treatment of a murine model of cancer. Methods: ...
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185 words Manuscript: 3342 words
متن کاملIL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences.
Immunostimulatory sequences (ISS) are short oligonucleotides containing unmethylated cytosine-phosphate-guanine (CpG) dinucleotides that stimulate innate immune responses through Toll-like receptor-9 on B cells and plasmacytoid dendritic cell (PDC) precursors. The anti-inflammatory cytokine interleukin (IL)-10 is predicted to be a potent inhibitor of many of the activities described for ISS, an...
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background: bacterial dna has immunostimulatory effects on different types of immune cells such as dendritic cells (dcs). application of dcs as a cellular adjuvant represents a promising approach in the immunotherapy of infectious disease and cancers. objectives: to investigate the effect of tumor antigen pulsed dcs in the presence of cpg-1826 in treatment of a murine model of cancer. methods: ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2002
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20020732